Abstract
Abstract We report a disulfide cross-linked poly(amino acid) nanogel that is completely disintegrable in the intracellular reductive environment by cleavage of the disulfide cross-links. A short-poly(ethylene glycol)-grafted poly(succinimide) was synthesized as an amphiphilic prepolymer to prepare poly(amino acid) nanogels that consisted of a hairy PEG shell and a disulfide cross-linked poly(amino acid) core. The nanogels were prepared by chemical conversion of the hydrophobic core of the cross-linked micelles into a hydrophilic poly(aspartic acid) network. The nanogels disintegrated into fully water-soluble and biocompatible residues in the reductive condition. Post-endocytic disintegration of the nanogel improved nuclear translocation and efficacy of an anticancer drug.
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