Complete responses in the irradiated field following treatment with chemotherapy with and without bevacizumab in advanced cervical cancer: An NRG Oncology/Gynecologic Oncology Group study

Abstract

treated by cone excision. Statistical analyses were performed with twosided tests and considered significant at a P value of b0.05. Results:A total of 102 patientswere included. Themean agewas 30 years (range, 18–56 years) and the mean age (standard deviation) of the first sexual intercourse was 17.4 (2.5) years. They had the mean of 8 (6) total sexual partners, 45.1% used condoms, and 39.2% used contraceptive pills. A total of 73.5% of womenwere nulliparous and 53.9%were smokers. The rate of spontaneous regression at 12 months was 65.7%, while 7.8% progressed and 26.5% had a persistent disease. Regression was observed in all cases that were p16-negative and 56.8% that were p16-positive (P=0.001) as well as all cases that were Ki-67-negative and 59.3% that were Ki-67-positive (P=0.011). High-grade squamous intraepithelial lesion in previous cytology, HPV16 infection, and HPV18 infection were statistically associated with non-regression compared to regression (P b 0.001, P=0.027, and P=0.008, respectively), while HPV negativity was significantly associated with regression (P=0.019). Conclusions: The high regression rate of CIN2 supports clinical observations in selected patients. Use of p16 and Ki-67 as biomarkers to predict CIN2 regression would have a great clinical value and could reduce unnecessary cone excision.