Abstract

The complete nucleotide sequence encoding the major outer membrane protein (MOMP) of Chlamydia trachomatis serovar L1 has been determined. Comparison of the inferred amino acid sequence with that derived for the N-terminus of the MOMP from C. trachomatis serovar L2 reveals a conservation of amino acid residues and a putative 22 amino acid signal peptide at the N-terminus of the protein. A region displaying homology with a cloned fragment containing a species-specific domain of the MOMP from C. trachomatis L2 is also observed. The coding region of the C. trachomatis L1 MOMP is preceded by a probable Shine-Dalgarno ribosome binding site and followed by a typical ϱ-independent transcription termination site.

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