Abstract
Methicillin-resistant Staphylococcus aureus (MRSA) clonal complex 8 (CC8) sequence type 239 (ST239) represents a predominant hospital-associated MRSA sublineage present worldwide. The Canadian epidemic MRSA strains CMRSA3 and CMRSA6 are moderately virulent members of this group but are closely related to the highly virulent strain TW20. Whole-genome sequencing of CMRSA3 and CMRSA6 was conducted to identify genetic determinants associated with their virulence.
Highlights
Methicillin-resistant Staphylococcus aureus (MRSA) clonal complex 8 (CC8) sequence type 239 (ST239) represents a predominant hospital-associated MRSA sublineage present worldwide
Several genetic components associated with virulence were detected on the chromosomes of both CMRSA3 and CMRSA6
CMRSA6 was found to carry a ⌽SP-like prophage that contains genes related to resistance and bacterial persistence
Summary
Methicillin-resistant Staphylococcus aureus (MRSA) clonal complex 8 (CC8) sequence type 239 (ST239) represents a predominant hospital-associated MRSA sublineage present worldwide. PacBio sequencing of CMRSA6 generated 57,790 reads covering 626,480,961 sequenced bases, with an average read length of 10,840 bp (longest read length of 53,372 bp).
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