Complete Genome Sequence of Human Norovirus GII.4_2006b, a Variant of Minerva 2006.

Zhihui Yang,Michael Kulka,Mark K Mammel

doi:10.1128/genomea.01648-15

Abstract

In 2006, the National Calicivirus Laboratory at the U.S. Centers for Disease Control and Prevention (CDC) confirmed multistate outbreaks of norovirus infection and identified two new GII.4 norovirus strains (Minerva and Laurens) through partial sequencing of the major capsid (VP1) gene. Here, we report the first complete genome sequence of the GII.4 Minerva isolate.

Highlights

In 2006, the National Calicivirus Laboratory at the U.S Centers for Disease Control and Prevention (CDC) confirmed multistate outbreaks of norovirus infection and identified two new GII.4 norovirus strains (Minerva and Laurens) through partial sequencing of the major capsid (VP1) gene
Norovirus (NV) infection is recognized as the leading cause of acute viral gastroenteritis worldwide in sporadic and outbreaks cases [1]
Noroviruses are genetically classified into seven genogroups, which are subdivided into different genetic clusters or genotypes [2]

Summary

Introduction

In 2006, the National Calicivirus Laboratory at the U.S Centers for Disease Control and Prevention (CDC) confirmed multistate outbreaks of norovirus infection and identified two new GII.4 norovirus strains (Minerva and Laurens) through partial sequencing of the major capsid (VP1) gene. Norovirus (NV) infection is recognized as the leading cause of acute viral gastroenteritis worldwide in sporadic and outbreaks cases [1]. The pandemic GII.4 variant, named GII.4 Minerva, was identified as one of two predominant outbreak strains (Minerva and Laurens) in the United States in late 2005/early 2006 [5, 6] and was sequenced to obtain the open reading frame (ORF) 2 and ORF3 coding regions

Results

Conclusion