Abstract
The genome sequence of the original human herpesvirus 6A (HHV-6A) (GS isolate) has never been determined. DNA from a very low passage (<5 times) HHV-6A GS stock was isolated and sequenced, making it the first HHV-6A of U.S. origin to be fully sequenced. Such a sequence will be helpful for comparative analysis with other HHV-6A strains, including the U1102 strain isolated from Uganda.
Highlights
The genome sequence of the original human herpesvirus 6A (HHV-6A) (GS isolate) has never been determined
The human betaherpesvirus subfamily is composed of 4 viral species: cytomegalovirus and the herpesvirus (HHV)-6A, HHV-6B, and HHV-7
Considering that strains GS and U1102 are from very different geographical regions and that a complete genome sequence from a North American isolate is lacking, it became important to obtain the entire genomic sequence of the original GS isolate, considering that HHV-6A is the type species of the genus
Summary
The genome sequence of the original human herpesvirus 6A (HHV-6A) (GS isolate) has never been determined. The human betaherpesvirus subfamily is composed of 4 viral species: cytomegalovirus and the herpesvirus (HHV)-6A, HHV-6B, and HHV-7. The original HHV-6 isolate GS belongs to HHV-6A and was first isolated in the United States in 1986 from subjects with lymphoproliferative disorders and AIDS patients (1). A second HHV-6A isolate from Uganda, U1102, was reported (2).
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