Abstract
The Actinobacteria, Corynebacterium pseudotuberculosis strain P54B96, a nonmotile, non-sporulating and a mesophile bacterium, was isolated from liver, lung and mediastinal lymph node lesions in an antelope from South Africa. This strain is interesting in the sense that it has been found together with non-tuberculous mycobacteria (NTMs) which could nevertheless play a role in the lesion formation. In this work, we describe a set of features of C. pseudotuberculosis P54B96, together with the details of the complete genome sequence and annotation. The genome comprises of 2.34 Mbp long, single circular genome with 2,084 protein-coding genes, 12 rRNA, 49 tRNA and 62 pseudogenes and a G+C content of 52.19%. The analysis of the genome sequence provides means to better understanding the molecular and genetic basis of virulence of this bacterium, enabling a detailed investigation of its pathogenesis.
Highlights
Caseous lymphadenitis (CLA) or cheesy gland [1] is highly prevalent in many regions of the world, resulting in huge and significant economic losses in agribusiness since it is responsible for a decrease in wool production and carcass quality [2]
Numerous reports have been published worldwide where mainly small ruminants are the carriers of the C. pseudotuberculosis
Histopathological examination of antelope carcasses from a South African game reserve, a part of their routine meat inspection, showed tuberculosis-like lesions. These lesions were characterized by the presence of encapsulated necrogranulomatous inflammation similar to CLA within the pulmonary tissues, in bronchial lymph nodes, liver, kidney and some other organs of the antelopes [11]
Summary
Caseous lymphadenitis (CLA) or cheesy gland [1] is highly prevalent in many regions of the world, resulting in huge and significant economic losses in agribusiness since it is responsible for a decrease in wool production and carcass quality [2]. Small ruminant populations like sheep and goats, and other mammals, such as bovines, pigs, deer, ovines, equines, and even, though rarely, in camels and humans, are the victims of Corynebacterium pseudotuberculosis [3,4,5,6]. The disease is characterized by the presence of caseous necrosis in external and/or internal lymph nodes [1,7]. Ulcerative lymphangitis, which is confined to the lymph vessels of extremities the hind legs, is a disease caused by this bacterium in the horse [8,9].
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