Abstract
Here, we report the complete polyprotein sequence of a dengue virus 2 strain isolated in Brazil. This virus belongs to the American genotype and has the ability to cause neurovirulence in immunocompetent adult mice. The data presented here may help understand the genetic determinants responsible for neurovirulence.
Highlights
We report the complete polyprotein sequence of a dengue virus 2 strain isolated in Brazil
We report here the near-full-length genome sequence of an American strain of DENV2 (JHA1 strain)
The partial sequencing of the envelope and nonstructural 1 (NS1) genes of the JHA1 strain showed that the virus belongs to the serotype 2 American genotype
Summary
We report the complete polyprotein sequence of a dengue virus 2 strain isolated in Brazil. We report here the near-full-length genome sequence of an American strain of DENV2 (JHA1 strain). This virus was isolated from a patient in Belém do Pará, Brazil, presenting with dengue fever (1), and this strain was observed to be neurovirulent in immunocompetent adult mice. The partial sequencing of the envelope and nonstructural 1 (NS1) genes of the JHA1 strain showed that the virus belongs to the serotype 2 American genotype.
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