Complete Genome Sequence of a Chinese Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus That Has a Further Deletion in the Nsp2 Gene

Guobiao Ji,Feifei Tan,Jinshan Zhuang,Yingying Li,Xiangdong Li,Kegong Tian

doi:10.1128/genomea.01770-15

Abstract

Here, we report the complete genome of a Chinese highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) characterized by a further 29-amino acid (87 nucleotides) deletion in its Nsp2-coding region compared to the prototype of the HP-PRRSV JXA1 strain.

Highlights

The highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) was classified into genotype 2 (North American genotype) of PRRSV which belongs to the order Nidovirales, family Arteriviridae
Compared with other classical type 2 PRRS viruses that emerged before 2006, the HP-PRRSV represented by JXA1 has a discontinuous 30-amino acid deletion in the Nsp2 gene [2]
We announce the genome of a novel HP-PRRSV strain GZgy15-1 that has a further 29-amino acids deletion in its Nsp2 gene compared with JXA1, which was not previously reported

Summary

Introduction

The highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) was classified into genotype 2 (North American genotype) of PRRSV which belongs to the order Nidovirales, family Arteriviridae. Since the first report of HP-PRRSV in 2006, it has become the predominant circulating field strain in Chinese swine herds [1]. Compared with other classical type 2 PRRS viruses that emerged before 2006, the HP-PRRSV represented by JXA1 has a discontinuous 30-amino acid (aa) deletion in the Nsp2 gene (amino acids 481 and 533 to 561) [2].

Results

Conclusion