Abstract
Marine Streptomyces are considered as important but poorly investigated resources for natural products. A new strain Streptomyces sp. R527F isolated from the Arctic Ocean was shown to produce multiple macrolide antibiotics and several new compounds. The entire genome was sequenced and analyzed to gain a better understanding of the biosynthetic capabilities for future studies. At least 30 gene clusters were detected scattered throughout the genome, responsible for biosynthesizing up to 11 classes of natural products. The complete genome sequence allows for natural product mining and biosynthesis, as well as serving as a reference for other studies such as genomic evolution and adaptation to cold Arctic sediments.
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