Abstract
Human adenovirus (HAdV) is a causative agent of acute respiratory disease, which is prevalent throughout the world. Recently there are some reports which found that the HAdV-3 and HAdV-5 genomes were very stable across 50 years of time and space. But more and more recombinant genomes have been identified in emergent HAdV pathogens and it is a pathway for the molecular evolution of types. In our paper, we found a HAdV-7 GZ07 strain isolated from a child with acute respiratory disease, whose genome was E3-partial deleted. The whole genome was 32442 bp with 2864 bp deleted in E3 region and was annotated in detail (GenBank: HQ659699). The growth character was the same as that of another HAdV-7 wild strain which had no gene deletion. By comparison with E3 regions of the other HAdV-B, we found that only left-end two proteins were remained: 12.1 kDa glycoprotein and 16.1 kDa protein. E3 MHC class I antigen-binding glycoprotein, hypothetical 20.6 kDa protein, 20.6 kDa protein, 7.7 kDa protein., 10.3 kDa protein, 14.9 kDa protein and E3 14.7 kDa protein were all missing. It is the first report about E3 deletion in human adenovirus, which suggests that E3 region is also a possible recombination region in adenovirus molecular evolution.
Highlights
Human adenoviruses (HAdVs) are implicated in a wide range of human diseases, including respiratory, ocular, metabolic, renal and gastrointestinal
We found a HAdV-7 strain isolated from a child with acute respiratory disease, with a large portion of E3 region deleted
Whole genome comparison and E3 region analysis HAdV-7 Gomen strain genome was chose as a reference strain for whole genome comparison [11]
Summary
Human adenoviruses (HAdVs) are implicated in a wide range of human diseases, including respiratory, ocular, metabolic, renal and gastrointestinal. They are responsible for 5-10% of lower respiratory tract infections in infants and children throughout the world. HAdV-7, a member of the B1 subspecies, causes acute respiratory disease (ARD). This pathogen is identified in epidemics, is highly virulent and is associated with clinical manifestations of considerable severity including residual lung damage and fatal outcomes [1]. Previous reports suggested that HAdV-3 and -5 are very stable across 50 years of time and space [2,3], which is common in DNA viruses.
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