Abstract
Mannheimia haemolytica is a respiratory pathogen affecting cattle and related ruminants worldwide. M. haemolytica is commonly associated with bovine respiratory disease complex (BRDC), a polymicrobial multifactorial disease. We present the first two complete closed genome sequences of this species, determined using an automated assembly pipeline requiring no manual finishing.
Highlights
Mannheimia haemolytica is a Gram-negative rod bacterium commonly associated with severe acute hemorrhagic fibrinonecrotic bronchopneumonia [1, 2] in feedlot cattle, it can be found in the nasopharynx of asymptomatic cattle
Viral infections, extreme weather changes, transportation, and other factors appear to predispose cattle to bronchopneumonia that is symptomatic of bovine respiratory disease complex (BRDC) [3, 4]
A dot plot of these contigs showed that the 5= end of the serotype A1 genome overlapped the 3= end by 6,021 bp with Ͼ99.8% pairwise identity, while the 5= end of the serotype A1 genome overlapped the 3= end by 3,144 bp with 99.9%
Summary
Mannheimia haemolytica is a Gram-negative rod bacterium commonly associated with severe acute hemorrhagic fibrinonecrotic bronchopneumonia [1, 2] in feedlot cattle, it can be found in the nasopharynx of asymptomatic cattle. The bovine respiratory disease complex (BRDC) progression to bronchopneumonia results from host, pathogen, and environmental interactions that are not completely understood. A typical BRDC outbreak occurs about 7 to 10 days after calves arrive at a feedlot.
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