Abstract
Background: Ketogenic diets have repeatedly been suggested for the treatment of cancer. To date, only a few case studies reporting long term benefits associated with such diets have been published. Case report: Here we present a case where recurrent cervical intraepithelial neoplasia (CIN), a premalignant condition of cervical cancer, was successfully treated with the paleolithic ketogenic diet. The patient had a history of high grade CIN in 2011, which was successfully treated with cervical conization and fractional curettage. In October 2015 she was found to have a recurrence of high grade CIN (HSIL: High Grade Squamous Intraepithelial Lesion). The patient was then commenced on the paleolithic ketogenic diet and her repeat Pap (Papanicolaou) smear three months later was found to have reverted to normal. The patient has remained on the paleolithic ketogenic diet for 26 months, her repeat smears have stayed normal, and she is free of symptoms and side effects. Conclusion: We conclude that the diet was effective and safe in this patient. As a major benefit the patient was able to avoid a hysterectomy, which is the standard treatment for recurrent high-grade CIN. We believe that the paleolithic ketogenic diet combines benefits of both paleolithic and classical ketogenic diets, while excluding their disadvantages.
Highlights
Ketogenic diets have long been suggested as an alternative approach to cancer management [1]
Human studies have shown that the classical ketogenic diet is relatively safe [1,5], they have provided little evidence that it is beneficial in cancer
We report a case of a patient with recurrent high grade cervical intraepithelial neoplasia (CIN) where following the paleolithic ketogenic diet reversed this condition as evidenced by gynecological cytology
Summary
Ketogenic diets have long been suggested as an alternative approach to cancer management [1]. In contrast to the prevailing view of cancer as a predominantly genetic disease, Seyfried [2] suggested cancer as a metabolic disease emerging from respiratory insufficiency coupled with compensatory fermentation, an idea which can be traced back to the original theory of Warburg [3]. Seyfried suggested this altered energy metabolism to be common to all cancer types irrespective of the tissue type [2]. As far as we know only two cases of following the classical ketogenic diet have resulted in long-term survival [6]. We report a case of a patient with recurrent high grade cervical intraepithelial neoplasia (CIN) where following the paleolithic ketogenic diet reversed this condition as evidenced by gynecological cytology
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