Abstract
<h3>To the Editor.—</h3> Complement-fixing activity to melanin-producing cells (CFA-MPC),<sup>1</sup>also known as melanin-producing cell autoantibody,<sup>2-4</sup>has been reported in serum samples from nine patients using the indirect immunofluorescent complement-fixation technique on normal human skin. Six patients<sup>2-4</sup>had vitiligo associated with type 1 polyglandular autoimmune disease,<sup>5</sup>including hypoparathyroidism, Addison's disease, and chronic candidiasis. The remaining three patients did not present with vitiligo but had candidiasis with or without hypoparathyroidism.<sup>1</sup>On the basis of these latter three cases Nordlund,<sup>1</sup>cited by Peserico et al,<sup>3</sup>suggested that CFA-MPC should not be considered the cause of vitiligo, as this factor was always associated with candidiasis but seldom with vitiligo. Until now, no follow-up studies were conducted on cases with CFA-MPC without vitiligo. <h3>Report of Cases.—</h3> Since 1980, we have conducted follow-up studies on nine patients with type 1 polyglandular autoimmune disease and chronic candidiasis. They
Published Version
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