Abstract
Hepatocellular carcinoma (HCC) and cholangiocellular carcinoma (CCC) are the most frequent primary hepatic malignancies...
Highlights
Hepatocellular carcinoma (HCC) and cholangiocellular carcinoma (CCC) are the most frequent primary hepatic malignancies [1]
Thresholds calculated for Mean, Median, Maximum and glcm Idmn resulted in sensitivities of 0.84/0.84/0.78/0.36, specificities of 0.55/0.55/0.58/0.68, PPVs of 0.68/0.69/0.68/0.57 and NPVs of 0.76/0.76/0.70/0.48, respectively
Our data indicates that Computed tomography (CT) textural analysis may aid differentiation of hepatocellular carcinoma (HCC) from CCC in the single portal-venous enhancement phase compared to direct calculation of tumor-to-liver attenuation ratio showing significantly higher tumor attenuation and tissue homogeneity in HCC
Summary
Hepatocellular carcinoma (HCC) and cholangiocellular carcinoma (CCC) are the most frequent primary hepatic malignancies [1]. Differentiation between HCC and intrahepatic CCC is achieved by considering clinical, laboratory and imaging findings [2]. Clinical settings for occurrence of both HCC and CCC may overlap or be clinically ambiguous, tumor markers may be found negative [4]. In these cases of clinical dilemmas, imaging has evolved to a major diagnostic tool with some morphologic and enhancement patterns being considered suggestive for each of these two entities [5,6,7,8]. The portal-venous phase is at least capable to make the differentiation between HCC and CCC. Morphologic features like capsule formation, portal vein infiltration, radiologic evidence of cirrhosis, etc. are unable to distinguish between these tumors and most of these tumors need to be differentiated histologically [12]
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