Abstract

Rheumatoid arthritis (RA) is a chronic autoimmune disorder. It generates joint inflammation and synovitis. Which influence more or less 20 % of the population in India. The arthritis symptoms are created step by step. The major symptom of RA is a pain in the joint. The high level of rheumatoid factor ( RF ) in the blood is most often associated with autoimmune disease such as rheumatoid arthritis & sjogren's syndrome. The Normal range of RF is from 0-20 IU / ml. The anti-arthritis activity evaluation can be studied by using an animal model. The anti-arthritis activity can be done using pithecellobium dulce leaves. The pithecellobium dulce is also called Manila tamarind. PD leaves are also used as astringent to treat antidiabetic activity. The phytoconstituent is existing in leaves are alkaloids, phenol, afezilin, glycoside, saponin, telephenoid, quericitin, dulcitol and laempferol. The fresh leaves are collected and dried to prepared the extract. The dried leaves were ground by using a blender has fine powder. In pithecellobium dulce leaf extract, various methods of extraction like methanol, ethanol, and aqueous extract used for many activities such as CNS depressant, Analgesic, Antidiarrhoeal, Anti-inflammatory and Anti arthritis activity. The ethanol extract of pithecellobium dulce has a significant Anti arthritis activity.

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