Complementary mechanisms of atenolol and diltiazem in the clinical improvement of patients with stable angina.

Abstract

The combination of atenolol with diltiazem has been shown to be useful in the treatment of patients with coronary artery disease. Eighteen patients with proven coronary artery disease, stable angina, and no previous myocardial infarction were studied before and after treatment with atenolol (100 mg/day) (9 patients) or diltiazem (180 mg/day) (9 patients). Ischemic threshold at stress test, pressure-rate product at ischemic threshold, direct oxygen consumption at ischemic threshold, and exercise ejection fraction were determined. There was a slight increase in the duration of exercise, maximal oxygen consumption, and ischemic threshold after treatment with each drug. Double product at ischemic threshold decreased from 20.9 to 19.8 (p = NS) with atenolol but increased from 20.1 to 21.9 (p = NS) with diltiazem. Conversely oxygen consumption at ischemic threshold increased with atenolol to nearly significant values from 17.2 to 23.6 (p = 0.067) but not with diltiazem (16.2 to 22.3; p = 0.16). Before treatment, exercise ejection fraction increased less than 10% or decreased from its resting values in all patients but 1 with atenolol and 1 with diltiazem, but exercise ejection fraction increased significantly after treatment with atenolol (60.6 to 67.5; p = 0.02) but not with diltiazem. This improvement was due to a significant reduction in end systolic volume (103.8 to 78.6; p = 0.019), despite a similar increase in heart rate and blood pressure in all patients.(ABSTRACT TRUNCATED AT 250 WORDS)