Complementary effect of oral administration of Lactobacillus paracasei K71 on canine atopic dermatitis.

Abstract

Atopic dermatitis is a common skin disease encountered in dogs. Glucocorticoids are commonly recommended for symptomatic therapy and well-tolerated adjunctive therapies may help to reduce the necessary dose and associated risks of chronic glucocorticoid use. The purpose of this study was to evaluate the complementary efficacy of oral administration of Lactobacillus paracasei K71 in canine atopic dermatitis (cAD). Forty one dogs with mild to moderate cAD were recruited by19 animal hospitals. Dogs were assigned to receive either the investigational agent (K71 group; n = 20) or cetirizine hydrochloride (control group; n = 21). Previously prescribed medications were allowed to be continued during the 12 week trial. Dogs were assessed by the investigators using the cAD Extent and Severity Index (CADESI) and a medication scoring system. Pet owners assessed their dogs using a visual analog scale (VAS) and pruritus scores. The CADESI scores, VAS and pruritus scores in both groups at 12 weeks were improved compared with their baselines. The CADESI and pruritus scores in the K71 group were slightly lower than those in the control group and the reduction of medication scores in the K71 group was significantly lower compared with the control group (P < 0.05; Student's t-test). Oral administration of K71 can be useful in dogs with cAD as a complementary therapy, by providing a steroid-sparing effect.