Complementary/combined treatment of depression in rats: Aloe Vera, fluoxetine, acupuncture. An experimental study

Abstract

BackgroundUnderstanding the effects of natural remedies and alternative therapies on animal behavior is crucial for both scientific research and potential therapeutic applications. Aloe vera, a succulent plant known for its medicinal properties, has been widely studied for its potential benefits in various health conditions. Acupuncture, a traditional Chinese medicine practice, involves the stimulation of specific points on the body to promote healing and balance. By assessing the behavioral changes in rats exposed to Aloe vera and acupuncture, this study aims to shed light on the potential benefits and mechanisms underlying these interventions. Aim of the studyThis study aims to investigate the impact of Aloe vera and acupuncture on rat behavior using an experimental approach. The findings from this research may contribute to our understanding of alternative treatments and their potential applications in both human and veterinary medicine. MethodIn this experiment, rats were divided into eight groups: one control and seven treatment groups. The rats received drugs, Aloe vera extract, or acupuncture once daily orally for 2 weeks. Their behavior was evaluated using the Open Field Test and The Forced Swim Test on days 1, 7, and 14. Blood samples were collected from the rats' hearts and analyzed to assess kidney and liver function. ResultThe results of the study showed that Aloe Vera extract, particularly at a dose of 150 mg/kg, exhibited significant antidepressant effects. The combination of Aloe Vera extract, fluoxetine, and acupuncture therapy yielded the highest antidepressant effects compared to other groups. Additionally, the Aloe Vera extract showed positive effects on kidney and liver function. Conclusionthe study suggests that Aloe Vera extract may have potential as an alternative or complementary treatment for depression. Its antidepressant effects were demonstrated, particularly at a dose of 150 mg/kg, and were further enhanced when combined with fluoxetine and acupuncture therapy. Further research is needed to determine the optimal dosage and understand the mechanisms behind these effects.