Abstract
6-Mercaptopurine is a thiopurine-derivative antimetabolite, which is used for the treatment of cancer, ulcerative colitis, Crohn’s disease, and autoimmune diseases. The aim of this research work was to evaluate the impact of the Trivedi Effect® on the physicochemical, and thermal properties of 6-mercaptopurine using the modern analytical technique. 6-Mercaptopurine powder sample was divided into two parts. One part of the sample was considered as a control sample (no Biofield Energy Treatment was provided), whereas the other part was treated with Biofield Energy Treatment remotely by a renowned Biofield Energy Healer, Dahryn Trivedi and termed as a treated sample. The particle size values in the treated 6-mercaptopurine powder sample were significantly decreased by 5.72%(d10), 5.16%(d50), 3.75%(d90), and 4.54%{D(4,3)}; therefore, the specific surface area was increased by 4.76% compared to the control sample. The PXRD peak intensities and crystallite sizes of the treated powder sample were significantly altered ranging from-25% to 14.12% and-35.09% to 71.3%, respectively; whereas the average crystallite size was decreased by 2.77% compared with the control sample. The latent heat of evaporation and latent heat of fusion of the treated sample was significantly altered by 3.05% and-39.48% compared with the control sample. The total weight loss was significantly increased by 9.72%; however, the residue amount was significantly decreased by 79.89% in the treated sample compared with the control sample. The maximum thermal degradation temperature of the 1st, 2nd, and 3rd peaks of the treated sample was increased by 1.54%, 0.13%, and 5.56% compared with the control sample. From the results, it was concluded that the biofield energy treatment might have generated a new polymorphic form of 6-mercaptopurine which may offer better solubility, dissolution, absorption, and bioavailability compared with the control sample. The Biofield Energy Treated 6-mercaptopurine would be very useful to design better pharmaceutical formulations that might offer better therapeutic response against acute lymphocytic leukemia, chronic myeloid leukemia, ulcerative colitis, Crohn’s disease, and autoimmune diseases.
Highlights
Mercaptopurine (1,7-dihydro-6H-purine-6-thione) is a thiopurine-derivative antimetabolite used for the treatment of cancer and autoimmune diseases
The Trivedi Effect®-Consciousness Energy Healing Treatment has a significant effect on the particle size, surface area, crystallite size, and thermal properties of 6-mercaptopurine
The melting point and ∆H fusion of the Biofield Energy Treated sample was decreased by -0.22% and -39.48% compared with the control sample
Summary
Mercaptopurine (1,7-dihydro-6H-purine-6-thione) is a thiopurine-derivative antimetabolite used for the treatment of cancer and autoimmune diseases. The mechanism of action involves inhibition of purine nucleotide synthesis and metabolism by obstructing an enzyme called phosphoribosyl pyrophosphate aminotransferase interference [1,2] It is used alone or with other anti-cancer drugs for the treatment of acute lymphocytic leukaemia, chronic myeloid leukaemia, ulcerative colitis, Crohn’s disease, and autoimmune diseases [3,4,5]. In order to improve the solubility, dissolution, absorption, and bioavailability of the pharmaceutical and nutraceutical compounds, scientists throughout the globe doing the extensive research work [13].
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