Abstract
In this study, a complementary analysis was performed to improve the precision of the determination of in vivo curcumin biodistribution after intravenous administration. Overall, similar curcumin biodistribution profiles were obtained using optical fluorescence imaging and mass spectrometry. Poor curcumin accumulation was observed in the heart, spleen, and kidney. However, noticeable accumulation of curcumin in the brain was only observed using fluorescence imaging, probably owing to the insufficient extraction of curcumin from the brain for mass spectrometry. In addition, an exact and reliable measurement of curcumin accumulation in tissues such as the liver, gallbladder, and pancreas was performed using mass spectrometry because of high autofluorescence. Taken together, complementary analysis using optical fluorescence imaging and mass spectrometry allowed the precise determination of curcumin in each tissue. Furthermore, this complementary analytical strategy could be used to elucidate the in vivo distribution of a wide range of fluorescent polyphenols.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
