Abstract
In 2014, specific recommendations for complement nomenclature were presented by the complement field. There remained some unresolved designations and new areas of ambiguity, and here we propose solutions to resolve these remaining issues. To enable rapid understanding of the intricate complement system and facilitate therapeutic development and application, a uniform nomenclature for cleavage fragments, pattern recognition molecules (PRMs) and enzymes of the lectin pathway and regulatory proteins of the complement system are proposed, and a standardization of language to designate different activation states of complement components is recommended.
Highlights
The complement system is composed of more than 50 different molecules and cleavage products including but not limited to pattern recognition molecules (PRMs), proenzymes, proteases, anaphylatoxins, opsonins, receptors, regulators, and multi-molecular complexes that are critical to host defense and maintenance of normal tissue homeostasis [1]
We propose that it is time to align the C2 nomenclature with the other complement proteins (Figure 1B, recommended nomenclature)
When the PRMs-MASPs complexes recognize ligands, lectin pathway (LP) complement activation is subsequently initiated upon MASP-2mediated cleavage of C4 and C2
Summary
The complement system is composed of more than 50 different molecules and cleavage products including but not limited to pattern recognition molecules (PRMs), proenzymes, proteases, anaphylatoxins, opsonins, receptors, regulators, and multi-molecular complexes that are critical to host defense and maintenance of normal tissue homeostasis [1]. We propose recommendations and updates for nomenclature regarding four of these unresolved issues: [1] the cleavage products of C2, [2] C1 complexes- activated molecules, native molecules, or proenzymes, [3] lectin pathway recognition proteins and enzymes and [4] Clusterin.
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