Abstract
1. 1. Serum from the Pacific hagfish, Eptatretus stouti,contains a complement-like protein (CLP). 2. 2. CLP from unfractionated hagfish serum and from affinity-purified preparations binds to yeast cell surfaces. 3. 3. Incubation with CLP enhances the phagocytosis of yeast by hagfish leukocytes. 4. 4. CLP-mediated opsonization can be inhibited by anti-CLP antibody, EDTA, d(+)mannose and l(+)rhamnose. 5. 5. Additional opsomic factors are also in hagfish serum.
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