Complement C1q Activates Canonical Wnt Signaling and Promotes Aging-Related Phenotypes

Abstract

(Cell 149, 1298–1313; June 8, 2012) The article above reported a role for complement C1q in promoting age-related phenotypes. Since publication, we have noticed that the upper panels shown in Figure 7F were incorrectly selected and labeled. The upper-right panel portrayed an image from aged C1qKO mice, not aged wild-type mice treated with M241, as originally labeled. The upper-left panel was correctly labeled as aged wild-type mice treated with PBS, but the magnification of both images in the top panels was incorrectly labeled and did not match the magnification of the bottom two panels. The corrected figure, with the upper-left panel now portraying an image from aged wild-type mice treated with PBS and the upper-right panel portraying an image from aged wild-type mice treated with M241, both taken with a 4× magnification (scale bars, 150 μm), is shown on the following page. We sincerely apologize for these mistakes and emphasize that the correction of these errors does not impact our conclusions. Complement C1q Activates Canonical Wnt Signaling and Promotes Aging-Related PhenotypesNaito et al.CellJune 08, 2012In BriefBest known for helping to clear pathogens as a complement component, C1q surprisingly also promotes cleavage of the Wnt coreceptor LRP6, activating Wnt signaling. Serum levels of C1q increase with age, potentially contributing to the increased Wnt signaling that is associated with age-related impairment in skeletal muscle regeneration. Full-Text PDF Open Archive