Abstract
Aim: To specify complement activation in RDS we investigated complement factors after surfactant substitution. Subjects: 36 preterm infants with clinical and radiological signs of RDS were enrolled. 23 of them responded to surfactant (R), wereas 13 did not (NR). 18 healthy preterm infants without evidence of RDS, infection or asphyxia served as controls (H). Gestational age (mean±SD) was 28.8±3.0 weeks, birthweight 1278±447g with no differences between the groups .Measurements: Clinical data were recorded and blood samples were taken at the age of 24 hours. Results: No differences between groups H and R were found for factor B and C5a, between groups R and NR for C4, C5a and function test. All other values (mean±SD) differed (p<0.05) between the 3 groups. Table
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