Competitive and non-competitive interaction of solvent with biopolymers at the helix-coil transition

Abstract

On the basis of generalized model of polypeptide chain (GMPC) as a microscopic theory of the helix-coil transition applicable to both polypeptides and DNA, the Hamiltonian of the model of solvent, which interacts with a biopolymer in both competitive and non-competitive ways, is introduced. It is shown that the partition function of this model is reduced to multipliers to the model without solvent. In this case thermal and entropic parameters of the theory are redefined. Based on calculation of the helicity degree and correlation length different cases of relation between parameters of competitive and non-competitive interaction are discussed.