Abstract
Abstract Excretion rates of conjugated [BSP(C)] and unconjugated [BSP(U)]-BSP into bile were correlated with the hepatic concentration of the respective forms of the dye during infusions of either BSP(C) or BSP(U) in guinea pigs and rats. Animals infused with BSP(C) contained only conjugated dye in the liver and excreted dye into the bile at much higher rates than animals infused with BSP(U). In the latter instance, both BSP(U) and BSP(C) were present in liver. Excretion rates of BSP(C) into the bile for any given content of BSP(C) in liver were much lower under these circumstances. The findings suggested that BSP(U) in the liver competes with and depresses the transport of BSP(C) into the bile, and that this accounts for lower maximal rates of dye excretion when BSP(U) rather than BSP(C) is administered.
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