Compensatory responses to early olfactory restriction.

Abstract

The emphasis on the effects of early olfactory restriction has been on the deleterious nature of the consequences of this abnormal early experience. While these effects are certainly present and dramatic, it is also the case that the olfactory system is left fairly intact by this experimental manipulation. If one asks what mechanisms may account for the preservation of the developing olfactory system in the face of diminished activity, there are a number of neural responses that could help the system compensate for the damage inflicted upon the system by the loss of early sensory stimulation. I describe what may be compensatory responses to the decrease in dopamine, the increase in norepinephrine, the structural changes induced in the glomeruli and the increase in cell death within the olfactory bulb that follow neonatal unilateral naris occlusion.