Abstract
Compensatory ovarian hypertrophy (COH) was examined in 144 normal or neonatally androgenized Sprague-Dawley female rats. Injections of either oil or 1.25 mg testosterone propionate (TP) were given on day 5. Left ovariectomy or sham-operation was performed on day 1, 10, 25, or 40, and the right ovary was removed 9 days later. Significant COH was found in the normal female on days 10, 34, and 49, but not on day 19. No significant hypertrophy was found until day 34 in the TP-treated females, after which a decrease in rate of ovarian growth and percentage of COH was observed. Even on days 34 and 49 androgenized females displayed less COH than controls. The results suggest that the sensitivity of the normal female's hypothalamichypophyseal system to ovarian secretions varies during prepuberal development and that neonatal androgen can impair the responsiveness of this system to changes in ovarian secretions. (Endocrinology 90: 1309, 1972)
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
