Abstract

The purpose of the study was to determine the maximum safe concentration of calcium and phosphate in neonatal parenteral nutrition (PN) solutions when various combinations of inorganic and organic salts are applied. Twelve PN solutions for neonatal use were aseptically prepared. Increasing concentrations of inorganic and organic calcium and phosphate were added to the standard formulas. Each admixture was separately tested according to the following conditions; after mixing, at 37 °C for 24 hr, and the maximum safe combination of calcium and phosphate were stored at 4 °C for 30 days and followed by 24 hr at 37 °C. Visual inspections and microscopic observation of undiluted PN solutions as well as the membrane filter after filtration of the PN solution, pH evaluation, and absorbance were examined. The safe maximum concentration of organic and inorganic calcium and phosphate were proposed individually for each composition of parenteral nutrition solutions. Surprisingly, organic calcium with organic phosphate showed precipitation but over the therapeutic range. The protective effect of amino acid was observed and higher concentrations of calcium and phosphate were free of precipitation. This work is valuable in daily practice as it allows an increase in the limits of calcium and phosphate in PN solutions for infants.

Highlights

  • Phosphate salts are inorganic as well as organic salts

  • The purpose of the study was to assess the risk of calcium phosphate precipitation when various concentrations of inorganic and organic calcium and phosphate salts are mixed in various combinations in standard pediatric parenteral nutrition (PN) solutions

  • This work is valuable in daily practice as it allows an increase in the limits of calcium and phosphate in PN solutions for infants

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Summary

Introduction

Phosphate salts are inorganic (sodium phosphate) as well as organic (sodium glycerophosphate, NaGP) salts. Some date confirms that NaGP and calcium chloride compatibility provides a clinical option for limiting aluminum contamination while providing sufficient calcium and phosphate to meet the needs of neonatal patients[9]. Borosilicate glasses, in particular, are known to have good chemical durability and are used commonly in the pharmaceutical industry as the primary container These glass containers, even when made from borosilicate glass, can produce some undesirable effects that unavoidably occur from being in contact with drug solutions in long-term storage. Parenteral nutrition products are contaminated with aluminum, especially those distributed in small-volume containers: calcium salts, trace elements, vitamins. The purpose of the study was to assess the risk of calcium phosphate precipitation when various concentrations of inorganic and organic calcium and phosphate salts are mixed in various combinations in standard pediatric PN solutions. Our study assists practitioners in preventing calcium and phosphate precipitates in parenteral solutions

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