Compatibility of Cephacetrile Sodium Injection

Abstract

The compatibility of cephacetrile with 71 additives was examined in 5% glucose solution con taming Vitamin B complex injections (thiamine hydrochloride, flavin adenine dinucleotide and pyridoxal phosphate injections). Each ampule or vial was dissolved in 50 ml of glucose solution, where a higher concentration was tenfold as high as that of usual preparation. Under this condition, Kanamycin sulfate ® Vistamycin ®, Futraful ®, Diamox ®, Neophyllin ®, Meylon ®, Stronger Neo Minophagen C ®, Proteamin 12X ®, 5-FU ® and Urokinase ® accelerated the degradation of cephacetrile. The compatibility of these additives were reexamined under practical condition in which each injection was admixed in 500 ml of glucose solution, and all the admixtures except for Neophyllin ® showed the residual amounts above 90% after 6 hr and were compatible under practical condition. White turbidity was found in the admixtures of FOY ®, Novamin ® and Wintermin ® which may be due to the formation of the salts of the componen ts with cephacetrile with low solubility.