Abstract
During secondary peritonitis, intra-abdominally formed fibrin entraps bacteria that are thereby difficult to eliminate by host defence mechanisms. Activating fibrinolysis may have beneficial effects on bacterial clearance and thus on inflammatory responses. Systemic fibrinolysis has risks of major bleeding complications. In this study, tissue-type plasminogen activator (tPA) was administered topically 24 hours after induction of peritonitis to examine the effects of fibrinolysis on local (abdominal) and distant (circulatory and pulmonary) inflammatory responses during polymicrobial peritonitis.
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