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Abstract
Decapsulated guinea pig testes were superfused with a mixture of [3H]testosterone (T) and [14C]androstenedione (A). Steady state isotopic data from these experiments were used to estimate, among other parameters, the uptake of steroids, the tissue concentrations of labeled T and A derived from each of the superfused tracers, and the ratio of labeled T and A released by the tissue to the medium. Concentrations of endogenous T and A were measured in testicular samples and, after supervision of decapsulated testis with buffer without steroids, in tissue and superfusate. The ratios of concentrations of T and A in tissue as well as of T and A released to the medium were not the same for labeled (exogenous) and unlabeled (endogenous) steroids. These findings indicate that superfused tracers do not adequately reflect the fate of the endogenously produced androgens. The results from this study can be interpreted on the basis of a model representing two or more spaces of distribution of T and A not equally accessi...
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