Abstract
Pharmacokinetics, the quantitative description of drug concentration-time profiles, is now of central importance in clinical pharmacology. This review paper provides a semitechnical overview of the field of population pharmacokinetics from the perspective of compartmental modeling. The development of population-based pharmacokinetic models is examined along with the basic types of kinetic drug disposition models and absorption. One-, two- and three-compartment models are considered, as well as the concept of the effect or biophase compartment. Differences between bolus drug dosing and continuous infusions of drugs are illustrated both mathematically and graphically, with emphasis on the concept of context-sensitive half-time and its clinical implications.
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