Abstract
Citalopram is one of a class of antidepressants known as selective serotonin reuptake inhibitors. Citalopram blocks the reuptake of serotonin at the serotonin reuptake pump of the neuronal membrane, enhancing the actions of serotonin on 5HT1A autoreceptors. SSRIs bind with significantly less affinity to acetylcholine, histamine and norepinephrine receptors than tricyclic antidepressant drugs Using UV spectrophotometer a simple, economical least time consuming and accurate method for comparison of different brand of citalopram, has been developed. The assay is based on the UV absorbance maxima at about wavelength of 244 nm using distilled water as solvent. Four different brand of citalopram was dissolved in buffer of pH 1, pH 4 and water and then various dilutions are prepared (200 ppm, 100 ppm, 50 ppm and 25 ppm). The absorbance of these drugs was measured at 244 nm against the solvent blank and the assay was calculated by using the absorbance of active. We obtain linear relationship of four brands of citalopram when diluted to form 200 ppm, 100 ppm, 50 ppm, 25 ppm and absorbance of all brand are maximum in pH 4 .Squared correlation coefficient value of all the brands of citalopram are well within the limit.
Highlights
Citalopram is white to off white fine crystalline powder which is freely soluble in water chloroform and ethanol
Citalopram is an antidepressant belonging to class “selective serotonin reuptake inhibitors” (SSRIs)
The drug is effective in reducing ethanol uptake in alcoholics and is used in depressed patients who suffer from tardive dyskinesia in preference to tricyclic antidepressants, which exaggerate this condition [8]
Summary
Citalopram is white to off white fine crystalline powder which is freely soluble in water chloroform and ethanol. In-vitro studies of citalopram shows that it is a potent and selective inhibitor of serotonin uptake ANS has less activity for reuptake of norepinephrine and dopamine [3]. It has no significant affinity for receptors such as cholinergic, GABA, histaminergic, dopaminergic, benzodiazepine or serotoninergic 5HT1A, 5HT2, 5HT1B and adrenergic α1, α2, β. 12-23% if drug eliminates in unchanged form through urine and 10% through feces [5] It is highly lipophilic and widely distributed throughout the body it cross the blood brain barrier. Dimethylcitalopram is a metabolite of citalopram that cannot cross brain barrier [6].
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