Comparitive Study of Antihypertensive Treatment with Enalapril and Atenolol on Oxidative Stress and Insulin Resistance in Essential Hypertension

Abstract

Hypertension is a heterogenous disorder in which patients can be stratified by pathophysiology characteristics that have a direct bearing, on the efficacy of specifically targeted antihypertensive medications, on the detection of potentially curable forms of hypertension and on the risk of cardiovascular complications.The study is done to compare the effect of antihypertensive treatment with Enalapril and Atenolol on oxidative stress and insulin resistance in patients with essential hypertension .Plasma Malonaldehyde(MDA), reduced Glutathione and Catalase were estimated to measure oxidative stress and fasting plasma Insulin to measure Insulin resistance.Total 57 hypertensive patients(31 patients on Enalapril and 26 on Atenolol drug) and 28 healthy controls are taken in the study.Plasma MDA was estimated by the method of Yagi.(Yagi 1984),erythrocyte reduced Glutathione by method of Beatle et.al,.Catalase activity in erythrocytes estimated by method of Aebi (Aebi,1984).Fasting plasma insulin estimated by using human insulin ELISA kit.The data is statistically analysed and the mean ,standard deviation values were calculated.In the present study ,we found that systolic blood pressure(SBP),diastolic blood pressure(DBP),Oxidative stress and insulin resistance were higher in hypertensive patients.Treatment with Enalapril reduces SBP,DBP,Oxidative stress ,insulin resistance and improves antioxidant system and insulin signalling more significantly than Atenolol.