Abstract
Even though abdominal aortic aneurysm (AAA) and coronary heart disease (CHD) are both related to atherosclerosis, there could be important differences in risk factors. Based on Malmö Diet and Cancer Cohort, the incidence of AAA and CHD was followed prospectively. Cox regression was used to calculate the association of each factor with AAA and CHD and hazards ratio were compared using a modified Lunn-McNeil method; 447 participants developed AAA and 3129 developed CHD. After multivariate adjustments, smoking, antihypertensive medications, lipid-lowing medications, systolic and diastolic blood pressures, apolipoprotein (Apo) A1 (inversely), ApoB, ApoB/ApoA1 ratio, total leukocyte count, neutrophil count, and neutrophil to lymphocyte ratio were associated with the risks of both AAA and CHD. When comparing risk factor profiles for the 2 diseases, smoking, diastolic blood pressure, ApoA1, and ApoB/ApoA1 ratio had stronger associations with risk of AAA than with risk of CHD, while diabetes and unmarried status showed increased risk of CHD, but not of AAA (all P values for equal association <.01). The results from this big population study confirm that the risk factor profiles for AAA and CHD show not only many similarities but also several important differences.
Highlights
Abdominal aortic aneurysms (AAAs) are a significant health burden, among elderly males with an estimate of 1.3% of deaths being caused by abdominal aortic aneurysm (AAA) in men aged 65 to 85 years in developed countries.[1]
A meta-analysis including 23 studies reported a positive association between Coronary heart disease (CHD) and the occurrence of subclinical AAA and showed that CHD is a strong predictor of future AAA events.[6]
We further investigated whether the observed association of factors with each outcome (AAA and CHD) in the separate analyses was similar
Summary
Abdominal aortic aneurysms (AAAs) are a significant health burden, among elderly males with an estimate of 1.3% of deaths being caused by AAA in men aged 65 to 85 years in developed countries.[1] Abdominal aortic aneurysms seldom cause obvious symptoms, except at rupture, when it is often fatal.[2] it is important to identify individuals at high risk of AAA. Coronary heart disease (CHD) and AAA share many cardiovascular (CV) risk factors and CHD is a common comorbidity in AAA, and vice versa.[3,4,5]. Epidemiological studies indicate that AAA and CHD share some common risk factors, such as age, male gender, hypertension, dyslipidemia, and smoking, which are promotors of atherosclerosis.[6,7,8] inflammatory responses in the aortic walls were observed in both diseases.[9]
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