Abstract
Introduction: Trigonella foenum-graecum L. (Fenugreek) seeds and Cordia myxa fruits have been known as agents with anti-diabetes effects in Iranian traditional medicine. We compared the effects of aqueous extracts of these plants on diabetes-induced cognitive dysfunction. Methods: In our study, rats were equally allocated to 4 groups (n=12/group) as follows: control; diabetic; diabetic rats treated with T. foenum graecum seeds extract (TE) (870 mg/kg BW); and diabetic rats treated with C. myxa fruit extract (CE) (500 mg/kg BW) for 30 days. Diabetes was induced by alloxan (120 mg/kg BW, ip). Cognitive dysfunction was determined through memory task and passive avoidance learning (PAL). Results: Diabetes resulted in cognitive impairment in PAL and memory task. CE and TE significantly reduced serum blood sugar (P<0.05) and brain lipid peroxidation (P<0.001). Moreover, treatment with both extracts prohibited learning and memory deficits in diabetic groups in comparison to the non-treated group; however, there was no significant difference between the groups that were treated with TE or CE. Conclusion: Aqueous extract of fenugreek seeds and C. myxa are effective in preventing diabetesinduced lipid peroxidation and memory loss in animal models of diabetes.
Highlights
Trigonella foenum-graecum L. (Fenugreek) seeds and Cordia myxa fruits have been known as agents with anti-diabetes effects in Iranian traditional medicine
In our study, rats were allocated to 4 groups (n = 12/group) as follows: control; diabetic; diabetic rats treated with T. foenum graecum seeds extract (TE) (870 mg/kg BW); and diabetic rats treated with C. myxa fruit extract (CE) (500 mg/kg BW) for 30 days
CE administration (500 mg/kg) decreased the elevated level of serum glucose in treated diabetic rats compared to the control diabetic animals (P < 0.001)
Summary
Trigonella foenum-graecum L. (Fenugreek) seeds and Cordia myxa fruits have been known as agents with anti-diabetes effects in Iranian traditional medicine. CE and TE significantly reduced serum blood sugar (P < 0.05) and brain lipid peroxidation (P < 0.001) Treatment with both extracts prohibited learning and memory deficits in diabetic groups in comparison to the non-treated group; there was no significant difference between the groups that were treated with TE or CE. Conclusion: Aqueous extract of fenugreek seeds and C. myxa are effective in preventing diabetesinduced lipid peroxidation and memory loss in animal models of diabetes. Along with other plants in Sistan and Baluchestan province, such as Prosopis farcta and Momordica charantia is a new candidate for novel research in the treatment of diabetes and obesity.[12-14] In this regard, two medicinal plants known for their hypoglycemic effects were selected for this study in order to compare their effects against diabetes-induced lipid peroxidation and memory impairment. We selected the aqueous plant extracts to mimic the conventional drugs
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