Abstract
Introduction: End-stage renal disease (ESRD) is a worldwide public health problem. ESRD reduces health-related quality of life. Quality of life is an important determinant in the mortality and morbidity of hemodialysis patients. However, several studies have suggested that high flux dialyzers increase dialysis adequacy and reduce mortality and morbidity in these patients. Objectives: This study aimed to investigate the effects of high flux and low flux dialyzers on the quality of life in hemodialysis patients. Patients and Methods: In this clinical trial, 93 patients who met the inclusion criteria were randomly assigned to two groups of high flux and low flux dialyzers. Before intervention, both groups filled demographic and quality of life questionnaires. They were undergone dialysis with two dialyzers (one group by high flux and another by low flux) three times a week for 6 weeks. Then quality of life questionnaire was filled by both groups once again. Results: The overall quality of life score was not significantly different in both groups before intervention (P=0.121). After intervention, however, high flux group attained a significantly higher mean score (54 ± 10.4) than low flux group (43.89 ± 11.64) (P<0.001). Conclusion: According to the results of this study, the use of high flux dialyzers can be a useful method to increase the quality of life in hemodialysis patients.
Highlights
End-stage renal disease (ESRD) is a worldwide public health problem
The results of this study showed a significantly higher quality of life in patients with high flux dialyzers than those treated with low flux dialyzers
Kantartzi et al compared the quality of life in hemodialysis patients with low flux and high flux dialyzers and showed that the quality of Quality of life General health Physical functioning Mental health Body aches Social function Symptoms and problems Effects of kidney disease Sexual function Sleep Patients satisfaction rating Cognitive function and quality of social interactions *Paired t test
Summary
End-stage renal disease (ESRD) is a worldwide public health problem. ESRD reduces health-related quality of life. Patients and Methods: In this clinical trial, 93 patients who met the inclusion criteria were randomly assigned to two groups of high flux and low flux dialyzers. Before intervention, both groups filled demographic and quality of life questionnaires. In the United States, the Patients with ESRD need to receive renal replacement therapy (RRT), including hemodialysis, peritoneal dialysis, or kidney transplantation [9] to survive. Each of these approaches has different effects on physical, psychological, and social health in these patients [10]. In 2014, the population of hemodialysis patients is estimated to be 2.662 million [14]; This means that 89% of dialysis patients depend on hemodialysis [13]
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