Abstract
Background: So many people worldwide have chronic periodontitis. Chemotherapeutic agents can reduce host responses to bacterial pathogens and as a result reduce bone loss. Objectives: The aim of this study was to compare the effect of antibiotics such as amoxicillin and metronidazole (AMX+MTZ) with ciprofloxacin (CPF) as an adjunct to scaling and root planing (SRP) in pocket depth (PD) and clinical attachment loss (CAL) in patients with moderate to severe chronic periodontitis. Methods: In this randomized double-blinded placebo-controlled clinical trials, 45 patients with chronic moderate to severe periodontitis were randomly divided into 3 groups: the control group which received SRP plus placebo, the test 1 group which received SRP plus AMX+MTZ, and the test 2 group which received SRP plus CPF. PD and CAL were measured in each group at 3 time points (baseline, 1 month and 3 months after SRP). Statistical analysis was done using a paired t test and ANOVA. Results: Mean PD and CAL in the test groups were compared to the control group and no significant changes were found (P<0.05). Most changes in PD and CAL were seen at one month after intervention. Better outcomes were seen in the test groups (test 2 better than test 1). Conclusions: AMX+MTZ or CPF as an adjunct to SRP had better outcomes but did not have any significant impact on reducing PD and CAL over one 1 and 3 months after treatment in patients with chronic periodontitis.
Highlights
IntroductionMany people worldwide have chronic periodontitis. Chemotherapeutic agents can reduce host responses to bacterial pathogens and as a result reduce bone loss
The aim of this study was to compare the effect of antibiotics; AMX+MTZ with CPF as an adjunct to scaling and root planing (SRP) in pocket depth (PD) and clinical attachment loss (CAL) in patients with moderate to severe chronic periodontitis
Moderate to severe chronic periodontitis was diagnosed in the selected patients, their disease was diagnosed by a periodontist after clinical examinations
Summary
Many people worldwide have chronic periodontitis. Chemotherapeutic agents can reduce host responses to bacterial pathogens and as a result reduce bone loss. Objectives: The aim of this study was to compare the effect of antibiotics such as amoxicillin and metronidazole (AMX+MTZ) with ciprofloxacin (CPF) as an adjunct to scaling and root planing (SRP) in pocket depth (PD) and clinical attachment loss (CAL) in patients with moderate to severe chronic periodontitis. Conclusions: AMX+MTZ or CPF as an adjunct to SRP had better outcomes but did not have any significant impact on reducing PD and CAL over one 1 and 3 months after treatment in patients with chronic periodontitis. Bacteria cause an increase in pocket depth (PD) and attachment loss [3,4,5] They invade periodontal tissues, so mechanical therapies are not sufficient and systemic antibiotic therapies are used [6,7,8]. The use of systemic antibiotics as a necessary adjunct in controlling bacterial infection was reported in previous studies [5,9,10,11,12,13]
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