Comparison the Difference of Thyroid Function Status between 2D & 3D CRT Treatment Technique in HNC Patients

Abstract

Introduction: Thyroid gland is an important endocrine gland which regulates metabolic activities in our body as well as regulates vital body functions including breathing, heart rate, central and peripheral nervous systems, body weight, menstrual cycle, cholesterol levels and much more. As thyroid gland placed in the same field area treated by radiation therapy of non-thyroid head and neck cancer patient, so it is a challenge to preserve the normal thyroid function after completion of treatment. Objective: To assess the comparison the difference of thyroid function status between 2D & 3D CRT treatment technique in HNC patients. Methods: It was a quasi-experimental study was conducted at National Institute of Cancer Research & Hospital (NICRH), Mohakhali, Dhaka, Bangladesh from November 2016 and ended in October’2017. Total of 60 patients with above mentioned criteria were selected and each arm got 30 patients. Patient with histopathology report proven carcinoma of head and neck receiving radiotherapy were selected from tumor board of NICRH. The present study were carried out on patients with biopsy proven malignancies of head and neck who attended the Radiotherapy Department for radiotherapy and who met the selection criteria of the study. Results: Total study population was 60 among which 30 were in arm A (2D) and 30 were in arm B (3D). Majorities of the patients in arm A were 41-50 years old (46.7%). The mean age of the arm A patients was 52.27 (±7.38) years and that of the arm B was 49.50 (± 13.55) years. Thirty patients of head & neck cancers were included in arm A of the study, i.e. 2D arm. Out of which 21 (70%) were male and rest 9 (30%) were female. Thirty patients of head & neck cancers were included in arm B of the study, i.e. 3D arm. Out of which 23 (76.7%) were male and rest 7 (23.3%) were female. Most of the patients in both arms were farmers (40% in arm A and 60% in arm B). There were 9(30%) oropharyngeal, 8(26.7%) hypopharyngeal and 13(43.3%) ........