Comparison Study of Major Thalassemia, Thalassemia Intermedia of Iraqi Patients and Control Groups for Effectiveness of Liver Enzymes

Abstract

Beta-thalassemia is an autosomal recessive disease caused by absence or reduction in the synthesis of the ?-globin chain, which is one of three special scientific types, thalassemia grand, secondary and medium. In Iraq, the ?-thalassemia is a real problem due to the lack of medicines and equipment during the exclusive periods of wars and insecurity. The aim of this study is to evaluate some liver enzymes among Iraqi thalassemia and ?-thalassemia patients and the volunteer group. The study included 100 patients (57 females and 43 males) who were divided into two groups (53 with major thalassemia and 47 with moderate thalassemia), with an average age ± SD (14.28). The study also included 30 healthy individuals (16 males and 14 females) with average age of 15.25 years as a control group. The groups were matched by gender and age and had the same geographical and socio-economic status. The colorimetric methods were used to estimate the values of serum transaminases (GOT, GPT), bilirubin and alkaline phosphatase (ALP). There were no statistically significant differences between primary thalassemia and the control group regarding, mean age, sex, WBC count and serum serotonin, while there was statistically significant differences between thalassemia (grand) and thalassemia (mean) compared to control groups (P=0.001) in regard to (GPT), (GOT), bilirubin and (ALP) values.