Abstract
This study aimed to evaluate the immune response and histological changes of two Gumboro disease vaccines. Two hundred, days old broilers were divided into 4 groups: group A was vaccinated with live attenuated infectious bursal disease (IBD) vaccine at 7 and 21 days of age, group B was vaccinated with Immune-Complex vaccine (Icx) at 1 day old, then all broilers of the groups A, B and C were vaccinated with ND vaccine at 10 and 24 days, while the group D was negative control. The blood was collected at 1, 7,14,21,28 and 35 days of age to obtain serum for ELISA. Samples of bursa from broilers of all groups at 14 and 28 days of age were submitted for histological examination. As a result of vaccination in group A the antibody titers are elevated after the 1st and 2nd dose of vaccination at 7 and 21 days. In group B this titer is increased from 21 day of age and reaches to peak at 35 day 7810±858 with significant difference, while in unvaccinated groups C and D the titer decreased gradually. The histological examination of bursal sections in group A and B varied at 14 and 28 days post vaccination and showed degeneration and necrosis of follicular lymphocytes compared with group and D. Thus we conclude that (Icx) vaccine improves the immune response after IBD and ND vaccination in comparison with live IBD vaccine.
Highlights
Infectious bursal disease (IBD), called Gumboro disease is a severe and contagious viral disease of young chicks associated with high morbidity and mortality
Days old broilers were divided into 4 groups: group A was vaccinated with live attenuated infectious bursal disease (IBD) vaccine at 7 and 21 days of age, group B was vaccinated with Immune-Complex vaccine (Icx) at first day old, all broilers of the groups A, B and C were vaccinated with ND vaccine at 10 and 24 days, while the group D was negative control
We conclude that (Icx) vaccine improves the immune response after IBD and ND vaccination in comparison with live IBD vaccine
Summary
Infectious bursal disease (IBD), called Gumboro disease is a severe and contagious viral disease of young chicks associated with high morbidity and mortality. It is a major poultry infection worldwide [1]. Immune complex IBD vaccine is attending the needs for hatchery vaccination [5]. The live vaccines, more hostile strains, produce troubles, such as bursal tissue destruction, immunosuppressive effect, weakly protected chickens, and the hazard of mutating to virulence. This study is an effort to evaluate the immune response and the histological changes in broilers using two different genera of vaccines against IBD on the bursal tissue response
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