Abstract
Two of the major determinants of cardiovascular disease, hypertension and hyperlipidemia, commonly coexist. There is high prevalence (5 -25%) of low high density lipoprotein (HDL) cholesterol and a higher prevalence of elevated Triglyceride (TGL) levels in hypertensive compared to normotensive individuals. Elevated total cholesterol (TC) levels augment the risk of cardiovascular disease associated with hypertension. This study aimed to determine the antihypertensive & pleiotropic effects of telmisartan and losartan in patients with mild to moderate hypertension. All the subjects were between the ages of 18 -65 years. 100 subjects were selected for the study and their serum total cholesterol, HDL, LDL, VLDL, Triglyceride, Systolic blood pressure, diastolic blood pressure, heart rate were analyzed at the beginning of the study and 12th and 24 the week. Adverse events are also noted in each visit. All data entered in SPSS 10 version and scores obtained were statistically evaluated using student t test, chi square test and ANOVA. The study showed both telmisartan and losartan good control over hypertension in patients. Telmisartan has pleiotropic positive effect on lipid profile.
Highlights
Systemic arterial hypertension is a condition that affects almost one billion people worldwide and is a leading cause of morbidity and mortality [1]
It is reported that only 32% of hypertensive patients manage to improve their lipid profile, while this percentage falls to 11% for control of both blood pressure (BP) and lipids [5]
Data analysis was performed by means of the SPSS statistical software package for Windows; results were expressed as the mean±SD.One-way analysis of variance (ANOVA) was used to compare baseline data
Summary
Systemic arterial hypertension is a condition that affects almost one billion people worldwide and is a leading cause of morbidity and mortality [1]. This disease is sometimes called the silent killer [2]. Two of the major determinants of cardiovascular disease, hypertension and hyperlipidemia, commonly coexist. Elevated total cholesterol (TC) levels augment the risk of cardiovascular disease associated with hypertension. A large proportion of the cardiovascular risk in patients with hypertension can be attributed to dyslipidemia. The high attendant cardiovascular risk when these two conditions coexist warrants a strict emphasis on dietary and pharmacological therapy to successfully achieve blood pressure control. It is reported that only 32% of hypertensive patients manage to improve their lipid profile, while this percentage falls to 11% for control of both blood pressure (BP) and lipids [5]
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