Comparison on different subcutaneous injection methods with peginterferon affa-2a solution

Abstract

Objective To observe the impact of local pain,skin reactions and residual dose of medication with different methods subcutaneous injection of peginterferon alfa-2a solution.Methods Using the self-control methods,80 chronic hepatitis B patients were injected peginterferon alfa-2a solution with the conventional and improved subcutaneous injection respectively.Then,observed and compared the effect of two injection methods.Results The patients' local pain (25％ vs 75％,u =6.39,P ＜0.01),local skin ecchymosis (97.50％vs 77.50％,u =3.8517,P ＜0.01) and the residual drugs[(0.011 ±0.008) vs (0.052 ±0.010)ml,t' =28.635 6,P ＜ 0.05] were lower in patients using improved subcutaneous injection method than in patients using conventional subcutaneous injection method.Patients and nurses were significantly approved the improved subcutaneous injection method than that of conventional injection method (97.50％ vs 35.00％,100.00％ vs 38.75％,P ＜ 0.01).Conclusions Injection of peginterferon alfa-2a solution with the improved subcutaneous injection will reduce the patients'local pain,ecchymosis and the residual amount of drugs,improve the accuracy of the dosage,lower the economic burden of patients and endorsed by the patients and nurses,which is better than conventional subcutaneous injection. Key words: Pain; Subcutaneous injection; Peginterferon alfa-2a solution; Skin reaction; Residual drugs; Approved degree