Abstract
Purpose; Hunteria umbellata has been found to have therapeutic potentials in the treatments of diseases such as yaws, peptic ulcers, diabetes, piles and infertility in Nigeria; hence, the statistical analysis on the determination of acute toxicity of Hunteria umbellata was carried out in mice.Methods; Data on the acute toxicity studies of the seed extract of Hunteria umbellata administered via the intraperitoneal route was analyzed using the two-parameter Weibull model.Results; The median lethal dose (LD50) was 1.61 g/kg of body weight. This result falls in the neighbourhood of the median lethal dose earlier obtained in previous reports.Conclusion; The results show that Hunteria umbellata may be slightly toxic when administered intraperitoneally.Keywords: Hunteria umbellata, Weibull model, Acute toxicity, Median lethal dose (LD50).
Highlights
Many plants have been used as substitutes to orthodox medicines in Africa due to the ease of obtaining them in bushes and forests
The statistical study of the toxicity of this plant is necessary for gaining knowledge of its toxic effect in relation to its consumption by humans. This present study was undertaken to statistically determine the acute toxicity of Hunteria umbellata extract administered to mice through intraperitoneal route with the aid of Weibull model and compare with probit analysis
In the determination of lethal dose at 50 % (LD50), Table 1 shows the various doses used in the acute toxicity studies and their corresponding log doses, mortality ratio of the animals and their corresponding probit values (n = 5 per group)
Summary
Many plants have been used as substitutes to orthodox medicines in Africa due to the ease of obtaining them in bushes and forests. This present study was undertaken to statistically determine the acute toxicity of Hunteria umbellata extract administered to mice through intraperitoneal route with the aid of Weibull model and compare with probit analysis. Various mathematical models have been used in the analyses of dose-response relationships to assess the toxic effects of chemical substances. To determine the toxic effect of Hunteria Umbellata plant, the median lethal dose (LD50) of the two-parameter Weibull model is employed.
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