Abstract
Comparison of weekly and single dose intraarticular recombinant human growth hormone injection on cartilage degeneration in osteoarthritic model of white New Zealand rabbits
Highlights
Osteoarthritis (OA) is a heterogeneous condition characterized by the defect of articular cartilage integrity accompanied by several pathological changes in all articular structures including the subchondral bone and synovium [2]
The weight gain was observed in all rabbits during the study, and there was no significant difference in the mean weight increase among all groups (P value 0.767)
The cartilage was softened with a Yoshimi score of 3, while histopathological appearance showed cloning and tearing that reached the transitional zone of the cartilage which was equal to 5 points on the Mankin score
Summary
Osteoarthritis (OA) is a heterogeneous condition characterized by the defect of articular cartilage integrity accompanied by several pathological changes in all articular structures including the subchondral bone and synovium [2]. This condition is followed by related signs and symptoms such as pain and decrease in joint function. The global prevalence of knee osteoarthritis increases with age. It was 16% in population aged 15 and over and was 22.9% in population aged 40 and over [3]. The worldwide burden due to this musculoskeletal disorder increased. As a leading cause of disability worldwide, OA has significantly increased the socioeconomic burden by 63.1% between 1990 and 2007 and by 31.4%between 2007 and 2019 [11]
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