Comparison of volumetric capnography and mixed expired gas methods to calculate physiological dead space in mechanically ventilated ICU patients

Abstract

Physiological dead space should be a routine measurement in ventilated patients but measuring dead space using the Douglas bag (DB) method is cumbersome and requires corrections for compressed ventilator gas. These factors make this method impractical in the critical care setting. Volumetric capnography (VCAP) offers a relatively simple solution to calculating dead space. Few studies have been conducted to directly compare dead space measured by VCAP and the DB method in critically unwell adults. Prospective observational study of 48 mechanically ventilated adults ICU patients. Dead space was calculated simultaneously using VCAP (CO(2)SMO) and the Bohr-Enghoff equation. In total, 168 paired readings were taken. Single-breath CO(2) waveform areas under the curve were computed automatically by software to calculate physiological dead space. The calculated value of P(Ē(CO(2))) was also recorded from the CO(2)SMO device. Exhaust ventilator gas was collected in a 10-l mixing chamber. P(Ē(CO(2))) was measured in the chamber following correction for compressed gas. The study demonstrated good agreement between physiological V(D)/V(T) calculated by VCAP and corrected (mean bias 0.03), and uncorrected (mean bias 0.02) Bohr-Enghoff method. There was good correlation between the two methods of measurement (VCAP vs corrected r(2) = 0.90 P < 0.001, VCAP vs uncorrected r(2) = 0.90, P < 0.001). There was good correlation between [Formula: see text] calculated by the CO(2)SMO and in the exhaust collected gas (mean bias 0.08). VCAP shows good agreement with Douglas Bag method in measuring physiological V(D)/V(T) over a wide range of dead space fractions.