Comparison of Visceral Fat Measures with Cardiometabolic Risk Factors in Healthy Adults.

Kyoungjune Pak,Jeong Gyu Lee,Seung Hun Lee,Ju Won Seok,In Joo Kim,Qinghua Sun

doi:10.1371/journal.pone.0153031

Kyoungjune Pak, Jeong Gyu Lee + Show 4 more

Open Access

https://doi.org/10.1371/journal.pone.0153031

Copy DOI

Abstract

We aimed to evaluate the associations of visceral adiposity with cardiometabolic risk factors in normal subjects with integrated 18F-Fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT). A total of 58 normal subjects who underwent 18F-FDG PET/CT scan for cancer screening were included in this study. Volume and average Hounsfield unit (HU) of visceral adipose tissue (VAT) was measured from CT components of integrated PET/CT. Standardized uptake values (SUVmax) of liver, spleen, lumbar spine and ascending aorta (AA) were measured from PET components of integrated PET/CT. Body mass index (coefficient 78.25, p = 0.0259), glucose (37.62, p<0.0001), insulin (348.90, p = 0.0011), logarithmic transformation of homeostatic model assessment index-insulin resistance (-2118.37, p = 0.0007), and VAT HU (-134.99, p<0.0001) were independently associated with VAT volume. Glucose (0.1187, p = 0.0098) and VAT volume (-0.004, p<0.0001) were found to be associated with VAT HU. Both VAT volume and VAT HU of whole abdominal cavity is significantly associated with cardiometabolic risk factors.

Highlights

According to the most recent estimates of the 2013 Korean national health and nutrition examination survey, 37.8% or men and 25.1% of women classified as obese[1]
The prevalence of obesity has increased over the last decade and numerous prospective cohort studies have shown that obese persons, defined by a body mass index (BMI), have an increased risk of hypertension, cardiovascular disease, and all cause mortality [1,2,3,4]
Subjects were divided into 2 groups according to visceral abdominal adipose tissue (VAT) volume and VAT Hounsfield unit (HU)

Summary

Introduction

According to the most recent estimates of the 2013 Korean national health and nutrition examination survey, 37.8% or men and 25.1% of women classified as obese[1]. The prevalence of obesity has increased over the last decade and numerous prospective cohort studies have shown that obese persons, defined by a body mass index (BMI), have an increased risk of hypertension, cardiovascular disease, and all cause mortality [1,2,3,4]. The distribution of fat depots, such as visceral abdominal adipose tissue (VAT), independent of overall obesity, has been associated with cardiometabolic risks [5, 6]. Several studies have shown the area of VAT, measured by single-slice computed tomography (CT) image at L4-5 intervertebral space, could reflect the amount of VAT and may be the predictor of cardiometabolic complications [7, 8]. Using a single slice of CT image to PLOS ONE | DOI:10.1371/journal.pone.0153031. Using a single slice of CT image to PLOS ONE | DOI:10.1371/journal.pone.0153031 April 4, 2016

Objectives

Methods

Results

Conclusion