Comparison of Various Obesity-Related Indices for Identification of Metabolic Syndrome: A Population-Based Study from Taiwan Biobank.

Pei-Yu Wu,Szu-Chia Chen,Jiun-Chi Huang,Ya-Chin Huang,Hsuan Chiu,Hsin-Ying Clair Chiou,Tai-Hua Chiu

doi:10.3390/diagnostics10121081

Abstract

This study aimed to evaluate the performance of 11 obesity-related indices, including body mass index (BMI), waist circumference, waist-to-height ratio, waist–hip ratio, a body shape index, abdominal volume index, body adiposity index, body roundness index, conicity index, visceral adiposity index (VAI), and triglyceride glucose (TyG) index, in identifying metabolic syndrome (MetS) in adults. The information of 5000 participants was obtained from the Taiwan Biobank. Logistic regression analyses were performed to determine the associations between MetS and obesity-related indices with odds ratio (ORs). The predictive performance of the indices to identify MetS was compared using receiver operating characteristic (ROC) curves and areas under curves (AUCs). Multivariate-adjusted logistic regression showed that the ORs for MetS increased across the quartiles of each index. ROC curves analysis demonstrated that TyG index had the greatest AUC in men (AUC = 0.850) and women (AUC = 0.890). Furthermore, VAI had the greatest AUC in men (AUC = 0.867) and women (AUC = 0.925) aged 30−50 years, while TyG index had the greatest AUC in men (AUC = 0.849) and women (AUC = 0.854) aged 51−70 years. Among the studied obesity-related indices, TyG index and VAI exhibited the best performance for identifying MetS in adults. TyG index and VAI may be the relevant indices to assess MetS in clinical practice.

Highlights

Metabolic syndrome (MetS) is a cluster of risk factors for cardiovascular (CV) diseases and diabetes mellitus (DM), including abdominal obesity, hyperglycemia, elevated blood pressure and dyslipidemia [1]
The data used in the present study were collected from the Taiwan Biobank (TWB), a general population-based research database comprised of cancer-free residents aged 30−70 years enrolled through 31 recruitment stations in Taiwan since 2008
After adjustments for age, pulse pressure, total cholesterol, low-density lipoprotein cholesterol (LDL-C), estimated glomerular filtration rate (eGFR), uric acid, smoking status and exercise habits, all obesity-related indices were significantly associated with MetS in both men and women, except for waist circumference (WC), a body shape index (ABSI), Abdominal volume index (AVI), and body adiposity index (BAI) in women

Summary

Introduction

Metabolic syndrome (MetS) is a cluster of risk factors for cardiovascular (CV) diseases and diabetes mellitus (DM), including abdominal obesity, hyperglycemia, elevated blood pressure and dyslipidemia [1]. MetS is associated with a high risk of developing DM [2], chronic kidney disease [3], stroke [4], CV diseases and all-cause mortality [5,6]. In Taiwan, the prevalence of MetS greatly increased from 13.6% to 25.5% based on two official Nutrition and Health Surveys conducted 12 years apart [8]. Considering the growing prevalence of MetS and its impact on public health, early identification and management of MetS is important to prevent the subsequent development of type 2 DM, CV diseases and other complications.

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Methods

Results